The invention provides mesoporous nanoparticles loaded within its pores with at least one loaded pharmaceutically active agent and at least one capping pharmaceutically active agent chemically coordinated with at least one ligand being boronic acid or derivative thereof on the surface of said pores; compositions comprising such mesoporous nanoparticles and uses there of.
The patent covers the unique mechanism of the unloading of composite chemotherapies in low pH and high lactate cells; furthermore it includes the use of targeting agents to increase the effectiveness of the platform.
|Publication number||WO2017149546 A1|
|Publication date||Sep 8, 2017|
|Filing date||Mar 2, 2017|
|Priority date||Mar 3, 2016|
|Inventors||Itamar Willner, Vered Heleg-Shabtai, Ruth Aizen, Sharon Etery, Natalie Enkin|
|Applicant||Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd|