The invention provides mesoporous nanoparticles loaded within its pores with at least one loaded pharmaceutically active agent and at least one capping pharmaceutically active agent chemically coordinated with at least one ligand being boronic acid or derivative thereof on the surface of said pores; compositions comprising such mesoporous nanoparticles and uses there of.

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017149546

The patent covers the unique mechanism of the unloading of composite chemotherapies in low pH and high lactate cells; furthermore it includes the use of targeting agents to increase the effectiveness of the platform.